Abstract We describe the case of a patient who developed microscopic polyangiitis (MPA) after silicone breast implantation. A 60-year-old woman who had undergone silicone breast implantation was admitted to our hospital with complaints of general malaise and hematoproteinuria.
She was diagnosed as having MPA with evidence of acute progressive renal failure, pulmonary hemorrhage, and positivity for myeloperoxidase- antineutrophil cytoplasmic antibody (ANCA). A renal biopsy showed severe necrotizing and crescentic glomerulonephritis with arteriolitis.
The patient received high-dose steroids and plasma exchange treatment, but died of progressive pulmonary hemorrhage and multiple cerebral hemorrhage. Silicone implantation is associated with scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. This case report indicates the possibility of the development of MPA after silicone breast implantation.
My Analysis: If silicone breast implantation is the real cause of this vasculitis disease, then there may be many women at risk. Since very few of the WG women patients that I know developed WG and did NOT have breast implants, in my opinion this particular trigger does not happen often.
One day we will probably recognize the difference between people who can have auto-immune diseases and other’s who do not… I think it will be either DNA or gene sequence. If so, I hope it happens soon.