ANCA Associated Vasculitis is a type of autoimmune inflammation caused by auto-antibodies. Normal antibodies are parts in the blood that are produced by the immune system to fight infectious agents (such as bacteria). Auto-antibodies are abnormal antibodies that attack one’s own cells and tissues (autos = self). ANCAs are auto-antibodies that attack the thick liquid residing between the cell membrane holding all the cell’s internal sub-structures (cytoplasm), except for the nucleus or internal portion of the cell, of a certain type of white blood cells called neutrophils. ANCA stands for Anti-Neutrophil Cytoplasmic Auto-antibody. When ANCAs attack these neutrophils, they cause the white blood cells to attack the walls of small and medium vessels in different tissues and organs of the body.
ANCA Associated Vasculitis encompasses Granulomatosis with Polyangiitis (GPA, formerly known as Wegener’s Granulomatosis), Microscopic Polyangiitis (MPA), Churg-Strauss Syndrome (CSS) and Renal (Kidney) Limited Form.
The website is here.
The mission of this foundation is to find a cure for AAV – WG, MPA, CSS, and renal forms. Anyone who is funding research into the cures for these diseases is a thumbs up in my book. We have to few medications and at this time there is NO cure for this disease.